 |
|
|
The focus of our research program is the structure determination of integral membrane proteins by X-ray crystallography and functional analysis of these proteins using biophysical, biochemical, and cell biological techniques. We study transporters embedded in the outer membranes of Gram-negative bacteria, which are surface accessible and therefore have the potential to be good vaccine and/or chemotherapeutic targets against infectious diseases. We also study the membrane associated or soluble protein partners that interact with outer membrane transporters to better understand how these systems function in vivo. Current topics in the lab include [1] small molecule and protein import across the bacterial outer membrane, [2] protein secretion by pathogenic bacteria, and [3] protein import across mitochondrial outer membranes. See more about our research HERE.
|
 |
|
|
- Jan 10 (1-2pm), Blg 40/Rm 1201/1203 - Katie Henzler-Wildman (Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis) "Conformational exchange in antiparallel EmrE: Insights into the mechanism of multidrug resistant transport". - Jan 15 - 20 - Gordon Conference - Ligand Recognition & Molecular Gating, Ventura, CA. - Feb 9 (1-5pm) - 2nd Annual MPIG Postdoc symposium, conference room in Cloister/Blg 60. Abstract deadline - Jan 25. - Mar 11 - 16 - Gordon Conference - Protein Transport Across Cell Membranes, Galveston, CA. - July 28 - Aug 1 - American Crystallographic Association (ACA) Annual Meeting, Boston, MA. - July 20 - 24, 2013 - American Crystallographic Association (ACA) Annual Meeting (2013), Waikiki, Hawaii.
|
|
 |
|
- 2011-Dec - Wishing all a Happy Holidays and New Year! - 2011-Dec - Best wishes to Nicole as she exits our lab and prepares for grad school! - 2011-Nov - Jim has found a new home at Emerald Biostructures, wishing him all the best in the next phase of his career!
| |
 |
|
Our Lab [ June 2011 ]
[ Left to right , Steve, Jim, Ann Marie, Adam, Travis, Nicole, Susan, Nick ] See more photos HERE.
|
|
 |
|
|
Noinaj, N., Easley, N.C., Oke, M., Mizuno, N., Gumbart, J., Boura, E., Steere, A.N., Zak, O., Aisen, P., Tajkhorshid, E., Evans, R.W., Gorringe, A.R., Mason, A.B., Steven, A.C., & Buchanan, S.K. (2012). Structural basis for iron piracy by pathogenic Neisseria. Nature (Research Article), (just accepted). [HTML] [PDF] Barnard TJ, Gumbart J, Peterson JH, Noinaj N, Easley NC, Dautin N, Kuszak AJ, Tajkhorshid E, Bernstein HD, & Buchanan, S.K. (2012). Molecular basis for the activation of a catalytic asparagine residue in a self-cleaving bacterial autotransporter. JMB, Jan 6;415(1):128-42. [HTML] [PDF] Noinaj N, Wattanasak R, Lee DY, Wally JL, Piszczek G, Chock PB, Stadtman TC, & Buchanan, S.K. (2012). Structural Insights into the Catalytic Mechanism of Escherichia coli Selenophosphate Synthetase. J. Bacteriology, Jan; 194(2):499-508. [HTML] [PDF] Yamashita, S., Lukacik, P., Barnard, T.J., Noinaj, N. Felek, S., Tsang, T.M., Krukonis, E.S., Hinnebusch, B.J. & Buchanan, S.K. (2011). Structural insights into Ail-mediated adhesion in Yersinia pestis. Structure, Nov 9;19(11):1672-82. [HTML] [PDF] Fairman, J.W., Noinaj, N. & Buchanan, S.K. (2011). The structural biology of β-barrel membrane proteins: a summary of recent reports. Curr Opin Struct Biol. 21, 523-531. [HTML] [PDF] Noinaj, N., Fairman, J.W. & Buchanan, S.K. (2011). The crystal structure of BamB suggests interactions with BamA and its role within the BAM complex. J. Mol. Biol., 407, 248-260. [HTML] [PDF] See the complete list of publications HERE. * Documents in PDF format require the free Adobe Acrobat Reader application for viewing.
|
|
 |
|
|
|
Last Updated January 8th, 2012 |
|
