Yang D, Rismanchi N, Renvoisé B, Lippincott-Schwartz J, Blackstone C, Hurley JH. Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. NSMB, 2008;
Epub PubMed | PDF
Lee HH, Elia N, Ghirlando R, Lippincott-Schwartz J, Hurley JH. Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science, 2008;
322:576-580. PubMed | PDF
Im YJ, Hurley JH. Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. Dev Cell, 2008;
14:902-13. PubMed | PDF
Canagarajah BJ, Hummer G, Prinz WA, Hurley JH. Dynamics of cholesterol exchange in the oxysterol binding protein family. J Mol Biol, 2008;
378:737-48. PubMed | PDF
Hurley JH. ESCRT complexes and the biogenesis of multivesicular bodies. Curr Opin Cell Biol, 2008;
20:4-11. PubMed | PDF
Hurley JH, Yang D Mit domainia. Dev Cell, 2008;
14:6-8. PubMed | PDF
Hierro A, Rojas AL, Rojas R, Murthy N, Effantin G, Kajava AV, Steven AC, Bonifacino JS, Hurley JH. Functional architecture of the retromer cargo-recognition complex. Nature, 2007;
449:1063-67. PubMed | PDF
Prag G, Watson H, Kim YC, Beach BM, Ghirlando R, Hummer G, Bonifacino JS, Hurley JH. The Vps27/Hse1 Complex Is a GAT Domain-Based Scaffold for Ubiquitin-Dependent Sorting. Dev Cell, 2007;
12:973-86. PubMed | PDF
Kostelansky MS, Schluter C, Tam YY, Lee S, Ghirlando R, Beach B, Conibear E, Hurley JH. Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell, 2007;129:485-98. PubMed | PDF | Supplement
Lee S, Joshi A, Nagashima K, Freed EO, Hurley JH. Structural basis for viral late-domain binding to Alix. NSMB, 2007;
14:194-9. PubMed | PDF
Shi H, Rojas R, Bonifacino JS, Hurley JH. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol, 2006;
13:540-8. PubMed | PDF
Hurley JH, Emr SD. THE ESCRT COMPLEXES: Structure and Mechanism of a Membrane-Trafficking Network. Annu Rev Biophys Biomol Struct, 2006;
35:277-98. PubMed | PDF
Kostelansky MS, Sun J, Lee S, Kim J, Ghirlando R, Hierro A, Emr SD, Hurley JH. Structural and Functional Organization of the ESCRT-I Trafficking Complex. Cell, 2006;
125:113-26. PubMed | PDF
Lee S, Tsai YC, Mattera R, Smith WJ, Kostelansky MS, Weissman AM, Bonifacino JS, Hurley JH. Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Nat Struct Mol Biol, 2006;
13:264-71. PubMed | PDF
Im YJ, Raychaudhuri S, Prinz WA, Hurley JH. Structural mechanism for sterol sensing and transport by OSBP-related proteins. Nature, 2005;
437:154-8. PubMed | PDF
Kim J, Sitaraman S, Hierro A, Beach BM, Odorizzi G, Hurley JH. Structural Basis for Endosomal Targeting by the Bro1 Domain. Developmental Cell, 2005;
8:937-47. PubMed | PDF
Miller GJ, Wilson MP, Majerus PW, Hurley JH. Specificity Determinants in Inositol Polyphosphate Synthesis: Crystal Structure of Inositol 1,3,4-Trisphosphate 5/6-Kinase. Molecular Cell, 2005;
18:201-12. PubMed | PDF
Prag G, Lee S, Mattera R, Arighi CN, Beach BM, Bonifacino JS, Hurley JH. Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, γ-ear-containing, ADP-ribosylation-factor-binding proteins. PNAS, 2005;
102:2334-9. PubMed | PDF
Canagarajah B, Leskow FC, Ho JY, Mischak H, Saidi LF, Kazanietz MG, Hurley JH. Structural mechanism for lipid activation of the Rac-specific GAP, β2-chimaerin. Cell, 2004;
119:407-18. PubMed | PDF
Hierro A, Sun J, Rusnak AS, Kim J, Prag G, Emr SD, Hurley JH. Structure of the ESCRT-II endosomal trafficking complex. Nature, 2004;
431:221-5. PubMed | PDF
Miller GJ, Hurley JH. Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase. Molecular Cell, 2004;
15:703-11. PubMed | PDF
Hickenbottom SJ, Kimmel AR, Londos C, and Hurley JH. Structure of a Lipid Droplet Protein: The PAT Family Member TIP47. Structure, 2004;
12:1199-1207. PubMed | PDF
Hurley JH. Leucine in the Sky with Diamonds. Structure, 2003;
11:1192-3. PubMed | PDF
Miller GJ, Mattera R, Bonifacino JS, and Hurley JH. Recognition of
accessory protein motifs by the gamma-adaptin ear domain of GGA3. Nat Struct
Biol, 2003; 10:599-606. PubMed | PDF
Prag G, Misra S, Jones EA, Ghirlando R, Davies BA, Horazdovsky BF, and
Hurley JH. Mechanism of Ubiquitin Recognition by the CUE domain of the
vps9p. Cell, 2003; 112:609-20. PubMed | PDF
Trievel RC, Flynn EM, Houtz RL, and Hurley JH. Mechanism of Multiple
Lysine Methylation by the SET Domain Enzyme Rubisco LSMT. Nat Struct Biol,
2003; 10:545-52. PubMed | PDF
Suer S, Misra S, Saidi LF, Hurley JH. Structure of the GAT Domain
of Human GGA1: A Syntaxin Amino-Terminal Domain Fold in an Endosomal Trafficking
Adaptor. PNAS, 2003; 100:4451-6. PubMed | PDF
Hurley JH. Membrane proteins. Adapting to life at the interface.
Chem Biol, 2003; 10:2-3. PubMed | PDF
Hurley JH. GAF domains: cyclic nucleotides come full circle. Sci
STKE, 2003; 2003:PE1. PubMed | PDF
Trievel RC, Beach BM, Dirk LMA, Houtz RL, and Hurley JH. Structure
and Catalytic Mechanism of a SET Domain Protein Methyltransferase. Cell,
2002; 111:91-103. PubMed | PDF
Kato Y, Misra M, Puertollano R, Hurley JH, and Bonifacino JS. Phosphoregulation
of Sorting Signal-VHS Domain Interactions by a Direct Electrostatic Mechanism.
Nat Struct Biol, 2002; 9:532-536. PubMed | PDF
Hurley JH, Anderson DE, Beach B, Canagarajah B, Ho YS, Jones E, Miller
G, Misra S, Pearson M, Saidi L, Suer S, Trievel R, and Tsujishita Y. Structural
Genomics and Signaling Domains. Trends Biochem Sci,, 2002; 27:48-53.
PubMed | PDF
Misra S, Puertollano R, Kato Y, Bonifacino JS, and Hurley JH. Structural
Basis for Acidic-Cluster-Dileucine Sorting Signal Recognition by VHS Domains.
Nature, 2002; 415:933-7. PubMed | PDF
Tsujishita Y, Guo S, Stolz L, York JD, and Hurley, JH Specificity
Determinants in Phosphoinositide Dephosphorylation: Crystal Structure of an
Archetypal Inositol Polyphosphate 5-Phosphatase. Cell, 2001; 105:379-89.
PubMed | PDF
Hurley JH, Tsujishita Y, Pearson MA. Floundering about at cell membranes:
a structural view of phospholipid signaling. Curr Opin Struct Biol,
2000 Dec; 10(6):737-43. PubMed | PDF
Ho YS, Burden LM, Hurley JH. Structure of the GAF domain, a ubiquitous
signaling motif and a new class of cyclic GMP receptor. EMBO, 2000
Oct 16; 19(20):5288-99. PubMed | PDF
Misra S, Beach BM, Hurley JH. Structure of the VHS domain of human
Tom1 (target of myb 1): insights into interactions with proteins and membranes.
Biochemistry, 2000 Sep 19; 39(37):11282-90. PubMed | PDF
Hurley JH, Misra S. Signaling and subcellular targeting by membrane-binding
domains. Annu Rev Biophys Biomol Struct, 2000; 29:49-79. PubMed | PDF
Tsujishita Y, Hurley JH. Structure and lipid transport mechanism
of a StAR-related domain. Nat Struct Biol, 2000 May; 7(5):408-14.
PubMed | PDF
Burden LM, Rao VD, Murray D, Ghirlando R, Doughman SD, Anderson RA, Hurley
JH. The flattened face of type II beta phosphatidylinositol phosphate
kinase binds acidic phospholipid membranes. Biochemistry, 1999 Nov
16; 38(46):15141-9. PubMed | PDF
Misra S, Hurley JH. Crystal structure of a phosphatidylinositol 3-phosphate-specific
membrane-targeting motif, the FYVE domain of Vps27p. Cell, 1999 May
28; 97(5):657-66. PubMed | PDF
Hurley JH. Structure, mechanism, and regulation of mammalian adenylyl
cyclase. J Biol Chem, 1999 Mar 19; 274(12):7599-602. PubMed | PDF
Hurley JH. The adenylyl and guanylyl cyclase superfamily. Curr
Opin Struct Biol, 1998 Dec; 8(6):770-7. PubMed | PDF
Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH. Structure
of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold
flattened for interfacial phosphorylation. Cell, 1998 Sep 18; 94(6):829-39.
PubMed | PDF
Grobler JA, Hurley JH. Catalysis by phospholipase C delta1 requires
that Ca2+ bind to the catalytic domain, but not the C2 domain. Biochemistry,
1998 Apr 7; 37(14):5020-8. PubMed | PDF
Hurley JH, Grobler JA. Protein kinase C and phospholipase C: bilayer
interactions and regulation. Curr Opin Struct Biol, 1997 Aug; 7(4):557-65.
PubMed | PDF
Zhang G, Liu Y, Ruoho AE, Hurley JH. Structure of the Adenylyl Cyclase
Catalytic Core. Nature, 1997; 386:247-53. PubMed | PDF
