39th Mid-Atlantic Protein Crystallography Meeting Program
May 28, 2009
Thursday afternoon, May 28 - Bioscience Research Building
Registration 1:00 PM 4:00 PM - Colonnade
Opening remarks: 3:30 - 4 pm - Lecture Hall, RM 1101
Norma Allewell (UMd)
Davies Symposium: 4 - 6:20 pm (4 speakers; 30 minutes plus 5 minutes discussion)
Session chair: Fred Dyda
Brian Matthews (U. Oregon) - Holey proteins and holy people
Alexander Wlodawer (NCI / NIH) - Back to the future: Or, how I finally decided to follow in David's footsteps by studying antibodies
Robert Stroud (UCSF) - Maxwell's demons and 'r breniniaethau chan Cymru
David Davies (NIDDK / NIH) - Fifty years of protein structure: from myoglobin to the innate immune system
Banquet and evening session: 6:30 to 10 pm - Adele H. Stamp Student Union, Grand Ballroom, RM 1206
Session Chair: Peter Sun
Peter Sun (NIAID / NIH)
Jessica Bell (VCU)
Steven Sheriff (Bristol-Myers Squibb)
Sandra Smith-Gill (NCI / NIH)
Friday morning, May 29 - Bioscience Research Building
Breakfast 7:30 8:30 am - Colonnade
Session I: 8:30 - 10:35 am Lecture Hall, RM 1101
Session chair: Jim Hurley
Trafficking and signalling (5 speakers; 20 minutes plus 5 minutes discussion)
John Sondek (UNC) - General and versatile regulation of phospholipase C isozymes
Adriana Rojas (NIDDK / NIH) - Crystallographic studies of sorting signal recognition by clathrin adaptor proteins
Steven Sheriff (Bristol-Myers Squibb - The structures of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different conformations
Daniel Leahy (JHU) - The influence of structure on the understanding and design of ErbB-targeted drugs
Peter Kwong (VRC / NIH) - From antibody to vaccine: a structure-based paradigm for HIV-1
10:35 - 11 am - Colonnade
Coffee
Session II: 11 am - 1:05 pm Lecture Hall, RM 1101
Session chair: Lorena Beese
Nucleic acids and beyond (5 speakers; 20 minutes plus 5 minutes discussion)
Cynthia Wolberger (JHU) - The unusual chemistry of Sir2 enzymes
Xinhua Ji (NCI / NIH) - How dicer dices
Michael Hast (Duke) - Structure and inhibition of protein prenyltransferases from human pathogens
Andres Larrea (NIEHS) - Scrunching during DNA repair synthesis
Nicole LaRonde-LeBlanc (UMd) - Ammonia tunneling and active site coupling in glutamine-dependent NAD+ synthetase
Friday afternoon
Lunch 1:05 - 2:30 pm Colonnade
Session III: 2:30 - 4:50 pm - Lecture Hall, RM 1101
Session chair: Wei Yang
Methods (4 speakers; 30 minutes plus 5 minutes discussion)
Paul Emsley (York, UK) - Coot
Paul Adams (LBNL) - Automated Structure Solution with PHENIX
Janet Smith (U Mich) - Microcrystallography for crystals large and small
Zbyszek Dauter (NCI / NIH) - Unusual OD-twinning in crystals of a fluorescent protein
Business meeting: 5:00 - 5:15 pm - Dean's Conference Room, RM 3101
Business meeting to decide next year's MACA host
Poster and Exhibitor Session: 5:30 - 7:30 pm - Seminar Room, RM 1103 and Colonnade
Refreshments served
Saturday morning, May 30 - Bioscience Research Building
Breakfast 7:30 - 8:30 am - Colonnade
Session IV: 8:30 am - 12 pm Lecture Hall, RM 1101
Session chair: Susan Buchanan
Breakthroughs and applications (7 speakers; 20 minutes plus 5 minutes discussion)
Joseph Ferrara (Rigaku) - Revolutionary products from visionary insights
Matt Benning (Bruker) - Advances in hardware and software tools for macromolecular crystallography
Jason McLellan (VRC / NIH) - Large-scale transient transfection of mammalian cells
Zygmunt Derewenda (UVA) - A microscopic view of protein crystallization
10:10 - 10:40 am
Coffee - Colonnade
Matt Warkentin (Cornell) - Slow cooling of protein crystals: A new approach for low- and variable temperature crystallographic data collection
Andrea Moon (JHU) - A Synergistic Approach to Problematic Protein Crystallography: Affinity Tag Crystallization and Surface Entropy Reduction
Jinghua Lu (NIAID / NIH) - Structural recognition and functional activation by pentraxins
Lunch: 12 pm (box lunch provided) - Colonnade